Scoring systems (such as APACHE 2 and SAPS2) have been developed to better stratify the risk profiles of ICU patients and to estimate their potential outcome. They largely differ in terms of clinical presentation, age, disease etiology, hemodynamics, treatment response as well as in prognosis. Patients admitted to an intensive care unit (ICU) represent a highly heterogeneous population. Optimal cut-off for the overall cohort was 11 and varied remarkably depending on the admission diagnosis: myocardial infarction (9), pulmonary embolism (9), cardiopulmonary resuscitation (17) and pneumonia (17). In a univariate Cox regression analysis for all patients MELD-XI was associated with increased long-term mortality (changes per score point: HR 1.06, 95%CI 1.05–1.07 p<0.001) and remained to be associated with increased mortality after correction in a multivariate regression analysis for renal failure, liver failure, lactate concentration, blood glucose concentration, oxygenation and white blood count (HR 1.04, 95%CI 1.03–1.06 p<0.001). Patients with a MELD-XI score >12 had pronounced laboratory signs of organ failure and more comorbidities.
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